BDBM16312 (4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-imidazolidine]-2',5'-dione::CHEMBL266497::Sorbinil
SMILES Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1
InChI Key InChIKey=LXANPKRCLVQAOG-NSHDSACASA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 58 hits for monomerid = 16312
Affinity DataIC50: 140nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 250nMAssay Description:Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lensMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:The compound was tested for the inhibition of Aldose reductase in rat lens assay.More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of aldose reductase from rat lens. Value ranges from 0.07 - 1.2More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of human placental aldose reductase (HPAR) activity with glyceraldehyde as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibitory activity against aldose reductase in rat lensMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Compound was tested for its ability to inhibit crude aldose reductase obtained from rat lensMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:In vitro inhibition of rabbit lens aldose reductase.More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibitory activity of the compound was determined against human placental aldose reductase (HPAR) with glyceraldehyde as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Concentration required to produce 50% inhibition of aldose reductase enzyme (the literature IC50 value for sorbinil is 0.07 uM)More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against human placenta aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+6nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Orange A column at day 8More data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of aldose reductase in rat lens by spectrophotometer analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction.More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Tested for in vitro inhibition activity against rat Aldose reductase (AR)More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Tested for in vitro inhibition activity against human Aldose reductase (human AR)More data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Inhibitory concentration to aldose reductase (ALR-2) obtained from rat lensMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction.More data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:In vitro inhibitory activity of compound against rat lens aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibitory concentration against rat ALR2 aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory concentration against human ALR2More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 249nMAssay Description:Inhibition of aldose reductase in rat lensesMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of aldose reductase in Fischer-344 rat lens homogenate by spectrometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 620nMAssay Description:Inhibition of Albino rat eye lens ALR2 assessed as NADPH oxidation by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 249nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Inhibition of N-terminal 6His-tagged human aldose reductase expressed in Escherichia coli BL21(DE3) mediated NADPH linked pyridine-3-aldehyde reducti...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Compound was tested for inhibitory concentration against rat lens aldose reductase (uncompetitive inhibition type)More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of crude aldose reductase of rat lensMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibitory concentration against aldose reductase obtained from rat lensMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of Aldose reductase (AR) from rat lens (RL)More data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory activity towards human placenta aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:In vitro inhibitory activity against Aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
Affinity DataIC50: 919nMAssay Description:Inhibitory Activity against Human recombinant Aldose Reductase (wild type)More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of aldose reductase from pig lensesMore data for this Ligand-Target Pair
Affinity DataIC50: 910nMAssay Description:Inhibition of human recombinant aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibitory activity against rat lens aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Sepharose 4B column at day 7More data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Orange A column at day 8More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Orange A column at day 8More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+6nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Orange A column at day 8More data for this Ligand-Target Pair
Affinity DataIC50: 990nMAssay Description:In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against rat lens aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibitory activity against bovine lens aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of rat lenses ALR2 using DL-glyceraldehyde as substrate preincubated for 10 mins followed by substrate addition measured for 4 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of Sprague-Dawley rat kidney ALR1 using sodium D-glucuronate as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 2 hits for monomerid = 16312
ITC DataΔG°: -9.05kcal/mole logk: 4.50E+6
T: 24.85°C
T: 24.85°C
ITC DataΔG°: -9.05kcal/mole −TΔS°: 3.32kcal/mole ΔH°: -12.4kcal/mole logk: 4.50E+6
pH: 8.0 T: 24.85°C
pH: 8.0 T: 24.85°C